2026-10-14T15:23:15Z https://www.scidb.cn/oai

10.11922/sciencedb.889 2021-08-26T13:01:17Z

2021-08-26 Data of a series of novel chiral biaryl monophosphonates doi:10.11922/sciencedb.889 en Herein, we report a highly efficient organocatalytic asymmetric arylation of p-quinone phosphonates and 2-naphthols. A series of chiral biaryl monophosphonates were obtained under mild conditions in excellent yields and enantionselectivities (up to 99% yield and 95% ee). This reaction is highly functional group tolerant and could be operated at gram scale with a low catalyst loading (0.5 mol %). Remarkably, our approach provides a green and readily access to novel chiral biaryl monophosphorus ligands. Compound 4ca was successfully converted to novel chiral biaryl monophosphorus ligands 7a, 7b and 8 with high enantionselectivities in three steps. Organocatalytic Asymmetric Arylation; Atroposelective Synthesis; Biaryl Monophosphorus Ligands Guodong Sun Zhuofei Deng Zhonghua Luo Zhongqing Wang Jiancun Zhang PUBLIC https://creativecommons.org/licenses/by/4.0/ dataset Science Data Bank