2026-10-13T02:31:43Z https://www.scidb.cn/oai

10.57760/sciencedb.010u6 2026-09-04T16:50:16Z

2026-09-04 Multi-omics profiling of spinal cord in SOD1-ALS mice across disease stages: transcriptomic and proteomic landscape doi:10.57760/sciencedb.010u6 en This dataset comprises transcriptomic and proteomic profiles of spinal cord tissues from SOD1 transgenic mouse model of amyotrophic lateral sclerosis (ALS) and wild‑type (WT) controls across different disease stages. Spinal cords were collected at multiple time points representing pre‑symptomatic, onset, and progressive stages of the disease. Total RNA and protein were extracted from lumbar spinal cord segments, and transcriptomic analysis was performed using [RNA‑seq / microarray], while proteomic analysis was conducted using [LC‑MS/MS / other method]. Differential expression analysis identified genes and proteins with altered expression between SOD1‑ALS and WT mice over the disease course. These data provide a comprehensive resource for understanding the molecular dynamics underlying ALS progression and for identifying potential therapeutic targets. amyotrophic lateral sclerosis; autophagy; spinal cord Yu Zhang Qi Niu PUBLIC https://creativecommons.org/licenses/by-nc-sa/4.0/ dataset Science Data Bank