2026-10-13T12:45:22Z https://www.scidb.cn/oai

10.57760/sciencedb.011jf 2026-09-13T20:08:33Z

2026-09-13 Hemoperfusion Combined with Medium-Cutoff Membrane Dialysis in Patients with End-Stage Renal Disease: Single-Session Reduction Ratios and Associations with Cardiovascular Events doi:10.57760/sciencedb.011jf en This two-center retrospective cohort study included 344 patients with end-stage renal disease (ESRD) receiving maintenance hemodialysis between January 2019 and January 2024, categorized by modality into an HP+HD group (hemoperfusion combined with medium-cutoff membrane dialysis, n=154) and an HD group (conventional high-flux hemodialysis, n=190). The index date was the start of the assigned modality; follow-up continued to the first composite cardiovascular (CV) event, death, transfer/loss to follow-up, or the study cutoff (31 January 2024). Patient-level, uncorrected single-session reduction ratios were calculated as (pre-dialysis concentration - post-dialysis concentration)/pre-dialysis concentration x100%. Time to first composite CV event was the primary cardiovascular outcome, analyzed with cumulative-incidence functions and Fine-Gray competing-risk regression (all-cause death as a competing event) and cause-specific Cox regression, stratified by center and adjusted for prior cardiovascular disease, hemoglobin, and age. All-cause mortality was a secondary outcome. hemoperfusion; medium-cutoff dialysis; end-stage renal disease; single-session reduction ratio; cardiovascular events; inflammatory markers; LASSO regression Fawen Cao PUBLIC https://creativecommons.org/licenses/by-nc-nd/4.0/ dataset Science Data Bank