2026-10-14T06:05:05Z https://www.scidb.cn/oai

10.57760/sciencedb.0122y 2026-09-10T14:05:48Z

2026-09-10 CLDN6 mediates the HIF-1α/PD-L1 signaling axis to promote immune escape in the hypoxic microenvironment of gastric cancer doi:10.57760/sciencedb.0122y en This dataset supports the findings of the paper entitled "CLDN6 mediates the HIF-1α/PD-L1 signaling axis to promote immune escape in the hypoxic microenvironment of gastric cancer." The dataset includes:Clinical retrospective cohort data (clinicopathological characteristics, hematological parameters, and follow-up data from 976 gastric cancer patients receiving immunotherapy);Single-cell RNA sequencing data (gastric cancer samples before and after neoadjuvant immunotherapy);Raw data from molecular biology experiments (Western blot, qPCR, immunofluorescence, ChIP-qPCR, Co-IP, etc.);Raw data from cellular functional assays (CCK-8, colony formation, flow cytometry, Transwell, ELISA, etc.);Raw data from animal experiments (tumor volume, body weight, flow cytometry, immunohistochemistry, Western blot, etc.).All data have undergone rigorous quality control and can be used to validate the core finding of this study: CLDN6 acts as a critical bridging molecule between HIF-1α and PD-L1, mediating immune escape in the hypoxic microenvironment of gastric cancer. Gastric cancer; Hypoxic microenvironment; HIF-1α; CLDN6; PD-L1; Immune escape 赵俊 EMBARGO https://creativecommons.org/licenses/by-nc/4.0/ dataset Science Data Bank