2026-10-14T11:30:35Z https://www.scidb.cn/oai

10.57760/sciencedb.013be 2026-09-23T11:03:59Z

2026-09-23 Replication and methodological audit of knee osteoarthritis transcriptomic signatures from public GEO cohorts: analysis code and derived tables doi:10.57760/sciencedb.013be en Analysis code (Python) and all derived result tables underlying the manuscript 'Independent replication and cross-cohort validation of knee osteoarthritis transcriptomic signatures, with three methodological corrections to the prevailing GEO analysis conventions'. The deposit covers discovery (GSE55235 synovium, GSE169077 cartilage), external validation (GSE55457, GSE89408, GSE114007) and a single-cell atlas (GSE152805). Raw data are public from GEO and are not redistributed. Every stochastic step uses a fixed seed (random_state=42); executed-versus-framework tiers are declared in Supplementary Table S18. knee osteoarthritis; transcriptomics; replication; bioinformatics; systemic inflammation; GEO Zeng, Xianghong Liu, Shengwen Chen, Wen-Yang PUBLIC https://creativecommons.org/licenses/by/4.0/ dataset Science Data Bank