2026-10-14T11:32:32Z https://www.scidb.cn/oai

10.57760/sciencedb.013qc 2026-09-24T14:22:00Z

2026-09-24 RankTieR: deterministic gene-set scoring and random-tie-breaking lottery diagnostics (code and reproduction package) doi:10.57760/sciencedb.013qc en This deposit contains the RankTieR R package (v0.1.0) and the full reproduction chain for the manuscript "Tie or Truth: Quantifying and Diagnosing Random-Tie-Breaking Instability in AUCell Gene-Set Scoring of Single-Cells". RankTieR is a deterministic mean-rank rank-AUC gene-set scorer; the package is bit-for-bit reproducible on tie-dense sparse single-cell matrices. The reproduction chain includes: (1) the sparse-count benchmark grid (3 sparsity levels x 5 gene-set sizes x 3 effect conditions, 30 replicates, 5 scoring methods, AUCell 20-seed redraws); (2) the lottery-ruler formalization (per-cell redraw SD sigma_L, signal-to-noise ratio R = |delta|/sigma_L, redraw flip rate F, with the standardized delta convention); (3) the retrospective-audit scripts with per-study mini-manifests and md5 checksums. Fixed random seed SEED0 = 20260922. Environment: R 4.5.3, AUCell 1.32.0, UCell 2.14.0. All audited datasets are public GEO resources; accession identifiers are disclosed in the manuscript supplementary materials. single-cell RNA-seq; AUCell; gene-set scoring; random tie-breaking; reproducibility; RankTieR; lottery ruler; retrospective audit 张疆华 PUBLIC https://mit-license.org dataset Science Data Bank