2026-10-13T04:26:05Z https://www.scidb.cn/oai

10.57760/sciencedb.02743 2022-09-20T11:03:45Z

2022-09-20 BNIP3-dependent mitophagy safeguards ESC genomic integrity via preventing oxidative stress-induced DNA damage and protecting homologous recombination doi:10.57760/sciencedb.02743 en We propagated Bnip3+/+, vector-bnip3-/-, ∆LIR-bnip3-/-, and WT-bnip3-/- ESCs routinely for 30 passages either under normal conditions or with NAC or H2O2 treatment. Then we performed whole genomic sequencing on each cell line at either initial passage or after propagation for 30 passages. Compared to Bnip3+/+ ESCs, the bnip3-/- ESC genome accumulated more mutations during long-term propagation. The details of data are available from the corresponding author on reasonable request. BNIP3; mitophagy; genomic integrity; DNA damage; homologous recombination Zhao Tongbiao PUBLIC https://creativecommons.org/licenses/by/4.0/ dataset http://www.doi.org/10.1038/s41419-022-05413-4 Sciencedb Data Bank