2026-10-12T10:48:40Z https://www.scidb.cn/oai

10.57760/sciencedb.03138 2022-11-24T17:08:34Z

2022-11-24 Defective Porous Carbon Polyhedra Decorated with Copper Nanoparticles for Enhanced NIR-Driven Photothermal Cancer Therapy doi:10.57760/sciencedb.03138 en Currently, there is tremendous interest in the discovery of new and improved photothermal agents for near-infrared (NIR)-driven cancer therapy. Herein, a series of novel photothermal agents, comprising copper nanoparticles supported on defective porous carbon polyhedra are successfully prepared by heating a Cu-BTC metal–organic framework (MOF) precursor at different temperatures (t) in the range 400–900 °C under an argon atmosphere. The copper nanoparticle size and carbon defect concentration in the obtained products (denoted herein as Cu@CPP-t) increase with synthesis temperature, thus imparting the Cu@CPP-t samples with distinct NIR absorption properties and photothermal heating responses. The Cu@CPP-800 sample shows a remarkable photothermal conversion efficiency of 48.5% under 808 nm laser irradiation, representing one of the highest photothermal efficiencies yet reported for a carbon-based photothermal agent. In vivo experiments conducted with tumor bearing nude Balb/c mice confirm the efficacy of Cu@CPP-800 as a very promising NIR-driven phototherapy agent for cancer treatment. Results encourage the wider use of MOFs as low cost precursors for the synthesis of carbon-supported metal nanoparticle composites for photothermal therapy. PTT; NIR Cancer Therapy; 癌症治疗 Shanyue Guan PUBLIC https://creativecommons.org/publicdomain/zero/1.0/ dataset Science Data Bank