2026-10-14T04:28:10Z https://www.scidb.cn/oai

10.57760/sciencedb.05776 2022-11-01T14:55:31Z

2022-11-01 Discovery of (E)-N1-(3-fluorophenyl)-N3-(3-(2-(pyridin-2-yl)vinyl)-1Hindazol-6-yl)malonamide (CHMFL-KIT-033) as a Novel c-KIT T670I Mutant Selective Kinase Inhibitor for Gastrointestinal Stromal Tumors (GISTs) doi:10.57760/sciencedb.05776 en Biochemical Kinase AssayMolecular ModelingAntiproliferation AssaysSignaling Pathway StudyApoptosis Effect ExaminationRodent Pharmacokinetics.Xenograft Model cKIT; GIST; kinase inhibitor Xuesong Liu Beilei Wang Cheng Chen Ziping Qi Fengming Zou Junjie Wang Chen Hu Aoli Wang Juan Ge Qingwang Liu Kailin Yu Zhenquan Hu Zongru Jiang Wei Wang Li Wang Wenchao Wang Qingsong Liu Jing Liu PUBLIC https://creativecommons.org/licenses/by-nc/4.0/ dataset http://www.doi.org/10.1021/acs.jmedchem.9b00176 Science Data Bank