2026-10-12T13:35:54Z https://www.scidb.cn/oai

10.57760/sciencedb.06791 2022-12-09T10:32:08Z

2022-12-09 Automated synthesis of gadopentetate dimeglumine through solid-liquid reaction in femtosecond laser fabricated microfluidic chips doi:10.57760/sciencedb.06791 en Despite the continuously increased requirement on automated synthesis of medicines for distributed manufacturing and personal care, it remains a challenge to realize automated synthesis which requires solid-liquid phase reactions. In this work, we demonstrated an automated solid-liquid synthesis for gadopentetate dimeglumine, the most widely used magnetic resonance imaging (MRI) contrast agent. The high-efficiency reaction was performed in a 3D microfluidic chip which was fabricated by femtosecond laser micromachining. The structure of the chip realized 3D shear flow which was essential for highly efficient mixing and movement of the solid-liquid mixtures. Ultraviolet visible (UV–vis) spectrometer was employed for in-line analysis to help automation of this system. Comparing with the round-bottom flask system, this synthetic system showed significantly higher reaction rate, indicating the advantage of the 3D microfluidic technology in micro chemical engineering. microfluidic chips; femtosecond laser; synthesis Ya Cheng Ming Hu Difeng Yin Wenbo Li Wei Chu Jianping Yu Miao Wu PUBLIC https://creativecommons.org/licenses/by-nd/4.0 dataset Science Data Bank