2026-10-14T13:45:59Z https://www.scidb.cn/oai

10.57760/sciencedb.07340 2023-02-13T14:08:21Z

2023-02-13 Analysis of Nitrogen-containing Compounds in Mouth-exhaled Breath by Electrospray Ionization Quadrupole Time-of-Flight Mass Spectrometry doi:10.57760/sciencedb.07340 en Nitrogen-containing compounds are important components in human breath. However, their origins have not yet been clearly understood. In this study, a modified electrospray ionization (ESI) source coupling with quadrupole time-of-flight mass spectrometry has been used for breath analysis. Fourteen nitrogen-containing compounds were identified in mouth-exhaled breath, and 10 of them were from the oral cavity and oropharynx. Moreover, 8 of these nitrogen-containing compounds were recognized as endogenous metabolites. This result provides important clues for exploring the biological origins of these nitrogen-containing compounds. Observation of the ion suppression phenomenon also indicates that breath analysis should be carried out after clearing of the oral cavity and oropharynx, or directly through nose-breathing to eliminate the influence of those nitrogen-containing compounds from the oral cavity. Nitrogen-containing compounds; ESI-MS; mouth-exhaled breath; nose-exhaled breath Wenzhao ZHOU Yan HONG, Xue ZOU Lei XIA Yan LU Chengyin SHEN Chaoqun HUANG Yannan CHU PUBLIC https://creativecommons.org/licenses/by/4.0/ dataset http://www.doi.org/10.2116/analsci.19N018 Science Data Bank