2026-10-14T02:27:27Z https://www.scidb.cn/oai

10.57760/sciencedb.07377 2023-02-14T10:35:17Z

2023-02-14 ANALYSIS OF THE BASELINE DRIFT ARTIFACT IN HADAMARD TRANSFORM SEPARATION TECHNIQUES doi:10.57760/sciencedb.07377 en The baseline drift artifact (BDA), namely, the baseline bias between the Hadamard transform (HT) spectrum and the signal averaging (SA) spectrum was unfortunately found in the I IT pulsed separation techniques, which makes the HT analytical chemistry face the challenge of non-stability and unreliability. In order to find out the origin and eliminate the BDA phenomenon, the multiplexing mechanism of Hadamard transform ion mobility spectrometry (HT-IMS) has been analyzed in this research. Through simulation and experimental comparisons, the non-ideal overlap defect in Hadamard multiplexing process was suggested as the cause for the BDA phenomenon. Eventually, with a correction method, the BDA phenomenon could be well addressed, which guarantees the reliability and stability of HT techniques without increasing the hardware complexity. baseline drift artifact; Hadamard transform; multiplexing mechanism; correction Hong Yan Su Jingming Tang Chaoli Huang Chaogun Liu Sheng Chu Yannan PUBLIC https://creativecommons.org/licenses/by/4.0/ dataset http://www.doi.org/10.21577/0100-4042.20170434 Science Data Bank