2026-10-13T16:01:54Z https://www.scidb.cn/oai

10.57760/sciencedb.07382 2023-02-14T11:16:33Z

2023-02-14 Discovery of 6 '-chloro-N-methyl-5 '-(phenylsulfonamido)-[3,3 '-bipyridine]-5-carboxamide (CHMFL-PI4K-127) as a novel Plasmodium falciparum PI(4)K inhibitor with potent antimalarial activity against both blood and liver stages of Plasmodium doi:10.57760/sciencedb.07382 en ChemistryPfPI4K kinase purificationBiochemical assayIn vitro inhibition assaysPlasmid constructsCRISPR/Cas9 systemIn vitro inhibition assays of PfPI4K mutated parasitesIn vivo blood-stage inhibition assaysIn vivo plasmodium liver-stage assay PI4K kinase; Kinase inhibitor; Malaria; Blood stage; Liver stage Xiaofei Liang Jing Liu Qingsong Liu PUBLIC https://creativecommons.org/licenses/by-nc-nd/4.0/ dataset http://www.doi.org/10.1016/j.ejmech.2019.112012 Science Data Bank