2026-10-14T14:08:20Z https://www.scidb.cn/oai

10.57760/sciencedb.07385 2023-02-27T14:28:01Z

2023-02-27 The cKIT kinase inhibitor CHMFL-KIT-64 was used in the treatment of gastrointestinal stromal tumors dataset doi:10.57760/sciencedb.07385 en Synthesis and characterization of compounds；Antiproliferative effects of compounds CHMFL-KIT-64 against a panel of c-KIT wt/c-KIT-T670I BaF3 cells；Selectivity profiling of compound CHMFL-KIT-64；Antiproliferation effects of compounds antiproliferation efects of compounds CHMFL-KIT-64 against a variety of GIST cancer cell lines；Cellular evaluation of compound CHMFL-KIT-64(for example cell cycle progression, apoptosis and signaling pathways);Antiproliferative effects of compounds CHMFL-KIT-64 against primary cells derived from GIST patients;In vivo PK/PD and efficacy evaluation of compound CHMFL-KIT-64;PK study of compound CHMFL-KIT-64 in mice, sprague dawley rats, and beagle dogs;Antitumor efficacy of CHMFL-KIT-64 in the BaF3-tel-c-KIT-T670I, BaF3-tel-c-KIT-D820G and BaF3-tel-c-KIT-Y823D xenograft mouse model. cKIT kinase; Gastrointestinal Stromal Tumor; kinase Yun Wu Beilei Wang Junjie Wang Shuang Qi Fengming Zou Ziping Qi Feiyang Liu Qingwang Liu Cheng Chen Chen Hu Zhenquan Hu Aoli Wang Li Wang Wenchao Wang Tao Ren Yujiao Cai Mingfeng Bai Qingsong Liu Jing Liu PUBLIC https://creativecommons.org/licenses/by-nc/4.0/ dataset http://www.doi.org/10.1021/acs.jmedchem.9b00280 Science Data Bank