2026-10-13T16:36:53Z https://www.scidb.cn/oai

10.57760/sciencedb.07865 2023-04-27T18:23:01Z

2023-04-27 Uncarialines A-E, new alkaloids from Uncaria rhynchophylla and their anticoagulant activity doi:10.57760/sciencedb.07865 en Uncarialines A-E (1-5), five undescribed monoterpene indole alkaloids, together with five known analogues were obtained from the stems of Uncaria rhynchophylla. Alkaloids 1-3 were unique 3,4-seco-tricyclic alkaloids with a 6/5/10 ring system, while 4 and 5 possessed a rare rearranged scaffold originated from corynantheine-type alkaloids with C-2/C-7 oxidation. Their structures were characterized by a comprehensive analysis of MS, NMR, and ECD. Their effects on blood clotting times of human plasma were evaluated and alkaloid 5 had a slight prolongation effect on both thrombin time and activated partial thromboplastin time (p < 0.001). Uncaria rhynchophylla; Monoterpene indole alkaloids; Uncarialines A-E; Anticoagulant activity Yu Zhang PUBLIC https://opendatacommons.org/licenses/by/1-0/ dataset Science Data Bank