2026-10-14T17:44:54Z https://www.scidb.cn/oai

10.57760/sciencedb.09206 2024-05-30T09:23:18Z

2024-05-30 The binding and structural basis of fox ACE2 to RBDs from different sarbecoviruses doi:10.57760/sciencedb.09206 en Foxes are known to be susceptible to SARS-CoV-2 in laboratory settings, and there have also been reports of natural infections of both SARS-CoV and SARS-CoV-2 in foxes. In this study, we assessed the binding capacities of fox ACE2 to important sarbecoviruses, including SARS-CoV, SARS-CoV-2, and animal-origin SARS-CoV-2 related viruses, demonstrated that fox ACE2 exhibits broad binding capabilities to the receptor-binding domain (RBD) from sarbecoviruses. fox ACE2; sarbecoviruses; cryo-EM 吴莹 PUBLIC https://creativecommons.org/licenses/by-nc/4.0/ dataset http://www.doi.org/10.1016/j.virs.2024.06.004 Science Data Bank