2026-10-15T06:11:09Z https://www.scidb.cn/oai

10.57760/sciencedb.09242 2024-05-31T11:30:59Z

2024-05-31 Fibroblast growth factor 21 exhibits neuroprotective effects by promoting 5-HT1AR-FGFR1 heteroreceptor complexes activation triggering MEK1/2-ERK1/2 signaling pathway doi:10.57760/sciencedb.09242 en  Approaches of promoting a neural milieu permissive for plasticity and resilience against neuronal injury are the important strategy for the treatment of a range of neurological disorders. Fibroblast growth factor 21 (FGF21) which is known for its role as a potent regulator of glucose and energy metabolism has also proved to be neuroprotective against various mental diseases. However, the underlying molecular mechanisms remain elusive. Here, we report a study in vivo and in vitro of the neuroprotective effects of FGF21 by triggering the signaling pathway of 5-HT1AR-FGFR1 heteroreceptor complexes in normal or abnormal neurological conditions.  Neurological damage; FGFR1-5-HT1AR heteromer; Neuroprotection ShulingWang PUBLIC https://creativecommons.org/licenses/by-nc-nd/4.0/ dataset Science Data Bank