2026-10-13T23:07:39Z https://www.scidb.cn/oai

10.57760/sciencedb.09326 2023-07-11T17:07:12Z

2023-07-11 Microwave-Assisted Synthesis of Celecoxib Nanocomposite for Enhancement of Solubility and Colon Cancer Targeting doi:10.57760/sciencedb.09326 en Microwave-assisted nanocomposite were prepared and evaluated using FTIR, DSC, XRD, solubility, in-vitro dissolution, SEM, and TEM. The drug-polymer ratio affects the celecoxib solubility and release at colonic pH. Study on solubility demonstrated that as the polymer concentration rises to the optimal level, the drug's solubility increases. Solubility of celecoxib-shellac nanocomposite (CSNC) and celecoxib-eudragit nanocomposite (CENC) had enhanced 26.22 μg/ml and 8.58 μg/ml, respectively, when using 1:3 ratio for CSNC and 1:4 ratio for CENC. Optimum ratio of drug to polymer showed release of drug 92.72±1.7% and 79.66±2.4% for CSNC and CENC respectively at the end of 8h at colonic pH. Nanocomposite; Celecoxib; pH-dependent polymer; microwave-assisted synthesis; solubility enhancement and colon targeting Rijawan R. Pathan Mohd Sayeed Shaikh Imran J. Syed Mamoon A. Qureshi Prajakta N. Acharya Mrunal K. Shirsat Aquil-ur-Rahim Siddiqui Rajkumar S. Moon PUBLIC https://opendatacommons.org/licenses/pddl/1-0/ dataset Science Data Bank