2026-10-12T11:32:36Z https://www.scidb.cn/oai

10.57760/sciencedb.09640 2023-07-24T13:42:42Z

2023-07-24 Lecanicilliums A-F, Thiodiketopiperazine-class Alkaloids from the mangrove sediment-derived fungus Lecanicillium kalimantanense doi:10.57760/sciencedb.09640 en Six new thiodiketopiperazine-class alkaloids, lecanicilliums A-F (1-6), were isolated from the mangrove sediment-derived fungus Lecanicillium kalimantanense SCSIO41702, together with 13 known analogous (7-19). Compound 1 contained an unprecedented 6/5/6/5/7/6 cyclic system. Their structures were elucidated by spectroscopic analysis, and the absolute configurations were further determined by quantum chemical calculations electronic circular dichroism (ECD) spectra. Biologically, 5, 7 and 16 displayed significant cytotoxicity against human lung adenocarcinoma cell line H1975 with IC50 values of 7.2~16.9 μM, and 5 showed antibacterial activity against five pathogens. Their structure-activity relationship is also discussed. Lecanicillium kalimantanense; thiodiketopiperazine-class alkaloids; cytotoxicity; toxicity; antibacterial activity Lin-Fang Zhong Shu-Hua Qi Juan Ling Xiao Liang Lian-Xiang Luo Chang-Nian Yang PUBLIC https://creativecommons.org/publicdomain/zero/1.0/ dataset Science Data Bank