2026-10-14T04:46:34Z https://www.scidb.cn/oai

10.57760/sciencedb.10567 2023-11-13T19:35:51Z

2023-11-13 Interactome profiling of Crimean-Congo hemorrhagic fever virus glycoproteins and identification of HAX1 as a host restriction factor against the virion packaging doi:10.57760/sciencedb.10567 en Crimean-Congo hemorrhagic fever virus (CCHFV) is a biosafety level-4 and World Health Organization-recognized priority pathogen requiring urgent Research & Development attention. The glycoproteins of CCHFV, Gn and Gc, are considered to play multiple roles in the viral life cycle by interactions with host cells; however, these interactions remain largely unclear to date. Here, we analyzed the cellular interactomes of CCHFV glycoproteins by affinity purification-quantitative mass spectrometry and identified 45 host proteins as high-confidence Gn/Gc interactors.  CCHFV; BSL-4 pathogen; Bunyavirus; glycoprotein (GP); interactome; Gn; HAX1; mitochondrion; Golgi apparatus; virus-host interactions. Shiyu Dai Yun-Jia Ning PUBLIC https://creativecommons.org/licenses/by-nc-nd/4.0/ dataset Science Data Bank