2026-10-13T12:50:15Z https://www.scidb.cn/oai

10.57760/sciencedb.11662 2024-08-09T11:13:02Z

2024-08-09 DHRS4-AS1 regulating the miR-362-5p/NPEPPS Axis doi:10.57760/sciencedb.11662 en Osteosarcoma (OS) is the most common primary malignant bone tumor. Recent evidence suggests that the novel long noncoding RNA DHRS4-AS1 serves an important role in cancer progression and metastasis. However, its function and molecular mechanism in OS remain largely unknown. In the present study, DHRS4-AS1 expression was detected in OS cells by quantitative PCR. Gain- and loss-of-function experiments were conducted to study the effects of DHRS4-AS1 on the proliferation and apoptosis of OS cells. The potential mechanism of DHRS4-AS1 was examined through bioinformatics analysis and rescue experiments. DHRS4-AS1 was downregulated in OS cell lines. DHRS4-AS1 depletion promoted proliferation and inhibited apoptosis in OS cells, whereas DHRS4-AS1 overexpression had the opposite effects. Further research suggested that DHRS4-AS1 inhibited OS progression by regulating the microRNA-362-5p/aminopeptidase puromycin sensitive axis. The present findings suggested that DHRS4-AS1 may serve as a potential therapeutic target for OS. Osteosarcoma; DHRS4-AS1; long noncoding RNAs; miR-362-5p; NPEPPS Wu Guofeng Lixin Zhu PUBLIC https://creativecommons.org/licenses/by-nc-sa/4.0/ dataset Science Data Bank