2026-10-14T18:07:12Z https://www.scidb.cn/oai

10.57760/sciencedb.12834 2023-11-10T17:35:56Z

2023-11-10 Impacts of hyperthermic chemotherapeutic agent on cytotoxicity, chemoresistance-related proteins, and PD-L1 expression in human gastric cancer cells (Submission to IJH) doi:10.57760/sciencedb.12834 en Our results showed that hyperthermia potentiates 5-Fu-mediated cytotoxicity in AGS cells. Furthermore, the combination of 5-Fu and hyperthermia inhibits both phosphorylated STAT3 and STAT3, while elevates phosphorylated Akt and ERK. In addition, 5-Fu/hyperthermia enhances ROS and suppresses superoxide dismutase 1. Chemoresistance-related proteins, such as multidrug resistance 1 and thymidylate synthase, are also suppressed by 5-Fu/hyperthermia. Interestingly, hyperthermia enhances 5-Fu-mediated induction of glycosylated PD-L1, but 5-Fu-mediated upregulation of surface PD-L1 expression is alleviated by hyperthermia. Hyperthermia; Chemotherapy; Gastric cancer 蘇柏全 Guan-Yu Chen Chun-Ming Yang Wei-Ting Chuang Meng-Chieh Lin Pei-Ling Hsu Chu-Wan Lee Chih-Cheng Cheng Shih-Ying Wu Bo-Syong Pan Hsin-Hsien Yu RESTRICTED dataset Science Data Bank