2026-10-14T16:00:11Z https://www.scidb.cn/oai

10.57760/sciencedb.13858 2024-09-26T09:20:49Z

2024-09-26 Nobiletin and CaSR doi:10.57760/sciencedb.13858 en The HPH rat model was constructed by 6-weeks consecutive hypoxia. Nobiletin or Sildenafil was administered daily via gavage for a duration of 2-weeks. Subsequently, hemodynamic parameters, HE staining and Masson staining, cytoplasmic calcium level of pulmonary arterial smooth muscle cells (PASMCs) were measured. Additionally, cellular thermal shift assays (CETSA), cell migration and proliferation assays, and immunoblotting were performed to explore the therapeutic effects and underlying mechanisms of Nobiletin on HPH in rats. Nobiletin; hypoxic pulmonary hypertension; calcium-sensing receptor Fajiu Li Qin Yin Wanhong Peng Jie Yang Cunyu Fan Qinru Wang Hongyu Gan Shiwei Zhang Xiao Hangfan PUBLIC https://creativecommons.org/licenses/by-nc-nd/4.0/ dataset http://www.doi.org/10.1007/s11418-025-01921-7 Science Data Bank