2026-10-14T15:45:37Z https://www.scidb.cn/oai

10.57760/sciencedb.15881 2024-02-07T11:20:07Z

2024-02-07 raw data for metabolomics and transcriptomics doi:10.57760/sciencedb.15881 en This dataset is the raw data for metabolomics and transcriptomics. After administering quinic acid orally to high-fat mice, changes in brain neuroinflammation were observed. Metabolomics revealed a significant increase in tryptophan metabolites indole-3-acetic acid and kynurenic acid, suggesting that quinic acid may be metabolized into tryptophan by gut microbiota. Then, these two substances were further administered orally to high-fat mice, and the same trend as quinic acid was observed. Transcriptomic analysis revealed that indole-3-acetic acid was expressed through DR3/IKK/NF- κB signaling pathway inhibits neuroinflammation in the brain. metabolomics; transcriptomics; quinc acid Xiao Guan Sen Li Yuwei Cai Tong Guan Yu Zhang Kai Huang Zhang Ze Wanqing Cao PUBLIC https://creativecommons.org/licenses/by-nc-sa/4.0/ dataset Science Data Bank