2026-10-14T21:09:05Z https://www.scidb.cn/oai

10.57760/sciencedb.15998 2025-07-04T11:38:43Z

2025-07-04 Oral inoculation of Fusobacterium nucleatum exacerbates ulcerative colitis via the secretion of virulence adhesin FadA doi:10.57760/sciencedb.15998 en The present study aimed to investigate the role of FadA adhesin in the colonization and invasion of F. nucleatum to epithelial cells using dextran sulfate sodium-induced colitis mice and molecular techniques. Oral inoculation of F. nulceatum strains harbored FadA adhesin further facilitated DSS mice in alveolar bone loss, disease severity, and mortality instead of FadA-deficient strains. In addition, CDH1 knockout mice manifested increased body weight, alveolar bone density, and alleviative disease severity in contrast with C57BL/6 mice. Moreover, FadA adhesin adheres to receptor E-cadherin and leads to phosphorylate of β-catenin and IκBα, regulating the NF-κB signaling pathway and up-regulating cytokines. Oral pathogens; Fusobacterium nucleatum; FadA adhesin; E-cadherin; Ulcerative colitis Li Donghao Li Zongwei Wang Lei Zhang Yan Ning Shoubin PUBLIC https://creativecommons.org/licenses/by/4.0/ dataset http://www.doi.org/10.1080/21505594.2024.2399217 Science Data Bank