2026-10-14T23:24:10Z https://www.scidb.cn/oai

10.57760/sciencedb.16870 2024-11-20T15:30:53Z

2024-11-20 A low pathogenic avian influenza A/Mallard/South Korea/KNU2019-34/2019 (H1N1) virus has the potential to increase the mammalian pathogenicity doi:10.57760/sciencedb.16870 en This study assessed the pathogenicity of KNU19-34 (H1N1) AIV isolated from wild aquatic birds using mouse and ferret models. KNU19-34 caused high mortality in mice and exhibited severe extrapulmonary infection in the heart and kidneys. In ferrets, the virus replicated rapidly in both the upper and lower respiratory tracts. Similar to pandemic H1N1, KNU19-34 preferentially bound to α2,6-linked sialic acid receptors and replicated efficiently in human lung cells. Genetic analysis identified several novel amino acid mutations (PB2-L464M, HA-S92P, NP-G16S, and NP-T433I), suggesting KNU19-34’s potential for mammalian adaptation and cross-species transmission. These mutations, along with increased replication ability, indicate a higher likelihood of the virus infecting mammals. H1N1; Zoonotic potential; Mutation; Avian influenza virus; Receptor binding specificity; Ferret; avian; influenza; mammalian Kim Jaemoo Kim Jungho Heo Suhyeon Yeom Chang-Hun Duong Bao Tuan Sung Haan Woo Yeo Seon-Ju Park Hyun Poo Haryoung Jihyun Yang PUBLIC https://creativecommons.org/licenses/by-nc-sa/4.0/ dataset http://www.doi.org/10.1016/j.virs.2024.12.005 Science Data Bank