2026-10-13T05:48:13Z https://www.scidb.cn/oai

10.57760/sciencedb.17909 2024-12-09T22:12:28Z

2024-12-09 Structural studies on Mycobacterial NudC reveal a class of zinc independent NADH pyrophosphatase doi:10.57760/sciencedb.17909 en Non-tuberculous mycobacteria (NTM) have emerged as an increasing threat to public health, due to the extreme antibiotic resistance. NADH pyrophosphatase (NudC) was proposed involving in mycobacterial resistance to the first line anti-tubercular drug isoniazid (INH) or its analog ethionamide (ETH), by hydrolyzing their NAD modified active forms (NAD-INH and NAD-ETH).  Non-tuberculous mycobacteria; X-ray crystallography; Zinc-free NADH pyrophosphatase; Mycobacterium abscessus; Nudix Lingyu Meng Zhaojian Sun Yulong Zhang Yan Dong Xiaoan Du Yujian Wu Yuan Yuan Yirong Sun Yong Xu Huaiwei Ding Jinsong Liu* Jinxin Xu* PUBLIC https://creativecommons.org/licenses/by/4.0/ dataset http://www.doi.org/10.1016/j.jmb.2024.168864 Science Data Bank