2026-10-12T02:09:23Z https://www.scidb.cn/oai

10.57760/sciencedb.18291 2024-12-13T21:06:03Z

2024-12-13 Spatial transcriptomics data of mouse thymus doi:10.57760/sciencedb.18291 en The thymus is a critical organ for T cell development and immune system function, but it undergoes significant structural and functional changes during aging, a process known as thymic involution. To investigate the spatial and cellular changes associated with thymic aging, we performed single-cell spatial transcriptomics on thymic tissues from young (4-week-old) and aged (52-week-old) C57BL/6J mice, with three biological replicates per age group. This dataset provides a detailed spatial and cellular map of the thymus at single-cell resolution, capturing changes in cell types, abundances, and spatial organization during aging. The results offer valuable insights into the cellular and spatial heterogeneity of the thymus and provide a resource for understanding immune system aging and potential therapeutic strategies. Spatial transcriptomics; thymus; mouse Jingwei Ma Liang Tang Jingxuan Xiao Bo Huang Junwei Liu PUBLIC https://creativecommons.org/licenses/by-nc-sa/4.0/ dataset Science Data Bank