2026-10-15T04:05:48Z https://www.scidb.cn/oai

10.57760/sciencedb.18651 2024-12-20T20:27:14Z

2024-12-20 A dataset of original image for Western Blot in manuscript of Network Pharmacology Prediction and Experiment Validation to Discover the Mechanism of Sophora Japonica Linn against Liver Cancer doi:10.57760/sciencedb.18651 en In vitro biological experiments showed that isorhamnetin and quercetin, the main active components of Sophora japonica Linn, had significant inhibitory effect on liver cancer cells HepG2. In addition, the expression of AKT and MEK proteins was downregulated, which proved that both isorhamnetin and quercetin promoted apoptosis by activating the PI3K/AKT and MAPK signaling pathways. In summary, our findings clarify the inhibitory effect of the active ingredients of Sophora japonica Linn against HepG2 cells and provide inspiration for its clinical application in the treatment of liver cancer. Liver Cancer; Sophora Japonica Linn; PI3K/AKT; MAPK Yahui PUBLIC https://creativecommons.org/licenses/by-nc/4.0/ dataset http://www.doi.org/10.21203/rs.3.rs-5771436/v1 Science Data Bank