2026-10-12T01:33:15Z https://www.scidb.cn/oai

10.57760/sciencedb.20464 2025-02-05T09:21:56Z

2025-02-05 Identification of Salivary Biomarkers in Colorectal Cancer by Integrating Olink Proteomics and Metabolomics doi:10.57760/sciencedb.20464 en This study integrated the diagnostic potential of saliva with multi-omics approaches for CRC research. We employed Olink PEA and LC-MS/MS to analyze protein and metabolite changes in the saliva of CRC patients. Using machine learning, we developed a protein-metabolite biomarker model with good diagnostic performance, offering novel insights for CRC screening and potential intervention strategies. colorectal cancer; saliva; biomarkers; olink proteomic; untargeted metabolomics Hairong Su Xiangyu Gu Weizheng Zhang Fengye Lin Xinyi Lu Xuan Zeng Chuyang Wang Weicheng Chen Wofeng Liu Ping Tan Liaonan Zou Bing Gu Qubo Chen PUBLIC https://creativecommons.org/licenses/by-nc-nd/4.0/ dataset http://www.doi.org/10.1021/acs.jproteome.5c00091 Science Data Bank