2026-10-12T13:49:11Z https://www.scidb.cn/oai

10.57760/sciencedb.26150 2025-06-06T14:43:48Z

2025-06-06 Therapeutic targets for non-rheumatic valvular heart disease: a proteome-wide Mendelian Randomization doi:10.57760/sciencedb.26150 en a comprehensive pQTL dataset of the human plasma proteome was utilized as exposure variables, and a proteome-wide MR analysis was conducted to identify plasma protein biomarkers linked to NRVD risk. Subsequently, the summary-data-based MR (SMR) and colocalization analyses were applied to enhance result reliability, and the safety of NRVD treatment targets was investigated through a phenome-wide association study (PheWAS). Non-rheumatic valvular heart disease; Mendelian Randomization; Plasma proteins; Therapeutic targets Jingwei Zhang Haoning Lan Zhidong Ye Yun Wang RESTRICTED dataset Science Data Bank