2026-10-13T10:16:08Z https://www.scidb.cn/oai

10.57760/sciencedb.27276 2025-09-05T11:54:52Z

2025-09-05 Umbilical Vein CD4+T-Cell Signatures as Predictors of Gut Microbiota Dysbiosis in Gestational Diabetes Mellitus-Exposed Neonates doi:10.57760/sciencedb.27276 en Our study reveals a novel immune-mediated mechanism by which gestational diabetes mellitus (GDM) alters neonatal gut microbiota colonization, with potential implications for early-life microbiome programming and metabolic health. By integrating 16S rRNA sequencing of meconium and flow cytometric analysis of umbilical vein blood, we demonstrate that GDM induces a Th2/Th1 immune imbalance in neonates, which drives pro-inflammatory microbial shifts and depletes beneficial taxa. Mediation analysis further identifies CD4⁺T cell subsets and cytokines as significant mediators of GDM-microbiota associations. gestational diabetes mellitus; gut microbiota; CD4+T cells; immune Xiaxia Cai Zhuo Hu Qi Zhou Qian Yang Yuchen Wei Xiaopei Qin Zhaoyang Chen Yandi Zhu Qinyu Dang Yadi Zhang Yulu Zhang Min Gao Kaihong Zeng Huanling Yu RESTRICTED dataset Science Data Bank