2026-10-12T17:31:38Z https://www.scidb.cn/oai

10.57760/sciencedb.27787 2026-02-27T09:36:06Z

2026-02-27 Safety-relevant experience reshapes neural codes for ambiguous threat in adolescents doi:10.57760/sciencedb.27787 en Visually threatening stimuli often carry ambiguous meanings, yet how safety-relevant experiences update the neural representations of these stimuli remains unclear. Adolescence is marked by the ongoing maturation of neural circuits supporting flexible contextual processing, which may shape how safety experience alters threat representations. The current study created a safety-relevant context in which visually threatening stimuli (animals, weapons) acquired meanings in relation to personal safety, with animals signaling danger and weapons conferring protection. Using 7T fMRI, we measured neural responses in 33 adolescents (MAge = 14.88 years, 19 females) during passive viewing before (Pre-task) and after (Post-task) the safety experience. At Post-task, protection stimuli elicited greater activation in the hippocampus, precuneus, and insula, reflecting experience-dependent safety updating. Threat stimuli showed more restricted changes in the precuneus, suggesting persistence of initial threat representations. Both stimulus types showed greater Pre-task activation in higher-level visual processing regions, reflecting vigilance to novel stimuli. MVPA indicated greater representational updating for protection than threat and showed convergent neural patterns for stimuli matched in safety meaning at Post-task, overriding original threat/protection categories. These findings may inform anxiety interventions explicitly training adolescents to recognize and use protective resources in aversive contexts to enhance safety updating, complementing traditional threat-extinction approaches. fMRI; neuroscience; brain Yubing Zhang PUBLIC https://creativecommons.org/licenses/by/4.0/ dataset Science Data Bank