2026-10-15T02:03:33Z https://www.scidb.cn/oai

10.57760/sciencedb.27890 2025-09-19T09:12:04Z

2025-09-19 Female-specific cone changes from Arr3-deficiency doi:10.57760/sciencedb.27890 en Heterozygous variants in ARR3, encoding cone arrestin, have been identified to cause high myopia with a unique X-linked female limited inheritance but the potential mechanism for the unusual anti-X-linked pattern is still unclear. Arr3 expression profiles showed that Arr3, with significant expression in retina since P14, was almost co-stained with Opsin red/green in cones including some partially co-stained with both Opsin red/green and Opsin blue. And then Arr3 knock-in mice and Arr3 knock-out rats were generated. Retinal single-cell RNA sequencing was perform to reveal the changes of cone sub-clusters and the differentially expressed genes (DEGs) to explain the mechanism of ARR3-eoHM. ARR3; X-linked female limited inheritance; Cones; Single-cell RNA sequencing Jiamin Ouyang Zhen Yi Yi Jiang Xueqing Li Gongpei Wang Yingwei Wang Wenting Du Shuowei Chen Yijun Dong Xueshan Xiao J. Fielding Hejtmancik Wenmin Sun Qingjiong Zhang PUBLIC https://creativecommons.org/licenses/by-nc-nd/4.0/ dataset Science Data Bank