2026-10-13T12:11:45Z https://www.scidb.cn/oai

10.57760/sciencedb.30129 2025-10-22T14:01:34Z

2025-10-22 Spatial epigenome revealed intratumor heterogeneity in breast cancer doi:10.57760/sciencedb.30129 en We leveraged the spatial ATAC-seq platform to profile the chromatin accessibility landscape of tumors from six BC patients. Our analyses revealed prominent heterogeneity within tumor regulatory modules and spatial variations in immune cell composition and stromal structures, offering a framework for investigation of the molecular architecture underlying ITH. Moreover, we identified two tumor subclones with potential common origin but distinct immune infiltration conferred by regulatory cascades, suggesting that epigenetic regulation may further contribute to the divergent tumor microenvironments and phenotypic diversity of these subclones. Our study provides novel insights into the molecular mechanisms driving ITH and opens up potential avenues for therapeutic intervention.  Breast cancer; Spatial ATAC-seq; Intratumoral heterogeneity; Tumor subclones; Tumor microenvironments qian yingying zhumiao Ren Chongyang Zhou Yeyong Xu Jian Dong Liang Zhang Guangyu Li Zhuohui Lv Jiaoyi Xing Qiaorui Zhang Guochun Peng Guangdun Liao Ning PUBLIC https://creativecommons.org/licenses/by/4.0/ dataset http://www.doi.org/10.1093/gpbjnl/qzag001 Science Data Bank