2026-10-12T20:44:32Z https://www.scidb.cn/oai

10.57760/sciencedb.30884 2025-11-07T18:26:28Z

2025-11-07 Human STING Interactome During ER to Golgi Transport doi:10.57760/sciencedb.30884 en The STING pathway is a central regulator of innate immunity that coordinates antiviral, antitumor and inflammatory programs. Upon sensing cyclic dinucleotides, STING exits the ER and traffics to the Golgi, yet how STING is preferentially packaged and delivered within the continuous stream of secretory cargo remains unknown. Here, we employed TurboID-based proximity labeling in living cells to capture the transient molecular environment of STING during ligand-driven transport. Affinity enrichment and LC-MS/MS were used to build a high-resolution map of STING-interacting proteins that govern ER-to-Golgi selectivity. These data clarify the basic cell-biological rules that license STING signaling and provide a comprehensive interactome resource for further mechanistic dissection. STING; TurboID; ER; Golgi; Transport Jiali Guan Jiayin Liang Tianxin Du Xuejing Zhao Xuechen Yang Binqian Zou Nan Zhang Yuxing Zhou Di Li Li Wan Yuting Guo Cong Ma Jun He EMBARGO https://creativecommons.org/licenses/by/4.0/ dataset Science Data Bank