2026-10-14T15:17:06Z https://www.scidb.cn/oai

10.57760/sciencedb.31159 2025-11-06T10:25:21Z

2025-11-06 genome sequence of synthetic onoclytic HSV-1 doi:10.57760/sciencedb.31159 en In the present research, we applied an HSV-1 synthetic genomics platform to construct two oncolytic viruses, oHSV-1.1 and oHSV-1.2. oHSV-1.1 had the virulence gene ICP34.5 and ICP47 deleted for attenuation, and oHSV-1.2 was additionally armed with murine granulocyte macrophage-colony stimulating factor (GM-CSF) and interleukin-12 (IL-12). Here we present the genome sequencing data of oHSV-1.1 and oHSV-1.2 Herpes simplex virus type I (HSV-1); Oncolytic virus; Synthetic genomics; GM-CSF; IL-12 xiao han Zhihong Hu Manli Wang Qiran Yin Jia Liu Hengrui Hu Jiang Li PUBLIC https://creativecommons.org/licenses/by-nc-nd/4.0/ dataset http://www.doi.org/10.1016/j.virs.2025.11.002 Science Data Bank