2026-10-13T05:28:20Z https://www.scidb.cn/oai

10.57760/sciencedb.31697 2026-03-27T09:57:38Z

2026-03-27 Single-cell RNA sequencing and bulk RNA sequencing of skin tissues from repeated-imiquimod-induced psoriasiform dermatitis mouse models and healthy controls doi:10.57760/sciencedb.31697 en This dataset contains single-cell RNA sequencing (scRNA-seq) data and bulk RNA sequencing generated from skin tissues of mouse models of imiquimod (IMQ)-induced psoriasiform dermatitis, including repeated-IMQ challenge models representing relapse-like psoriasiform inflammation and healthy control mice. Skin samples were collected from male C57BL/6 mice aged 6–8 weeks.The dataset was generated to characterize the cellular composition, transcriptional programs, and immune microenvironment associated with skin inflammation induced by repeated IMQ challenge. In particular, it provides a resource for investigating tissue-resident memory T-cell-related features, inflammatory signaling, keratinocyte states, and multicellular communication networks in a repeated-IMQ-induced psoriasiform dermatitis mouse model.These data may be useful for studies of psoriasis-associated skin inflammation, immune memory, relapse-related mechanisms, tissue-resident immune cells, and comparative transcriptomic analyses of experimental mouse models. psoriasis; psoriasiform dermatitis; imiquimod; repeated IMQ challenge; relapse-like inflammation; single-cell RNA sequencing; scRNA-seq; skin; mouse model; C57BL/6; tissue-resident memory T cells; TRM; skin immunity Xin Tong Zhan Zhang Zihao Li Chengxin Li Rui Wang Xuming Zhou EMBARGO https://creativecommons.org/licenses/by-nc/4.0/ dataset Science Data Bank