2026-10-14T12:03:00Z https://www.scidb.cn/oai

10.57760/sciencedb.32167 2025-11-26T16:59:35Z

2025-11-26 Roseburia intestinalis ameliorates NAFLD by delivery of Butyric acid via derived Extracellular Vesicles doi:10.57760/sciencedb.32167 en  We first conducted a cross-sectional analysis of gut microbiota in well-phenotyped obese individuals with or without NASH, carefully controlling for dietary confounders. Candidate bacteria associated with disease status were identified and subsequently validated in a high-fat diet (HFD)-induced murine NASH model via live bacterial supplementation. EVs were isolated from these candidate strains and administered to mice to assess their functional impact. Multi-omics approaches, including hepatic transcriptomics, proteomics, and metabolomics, were integrated with in vitro macrophage assays to delineate the underlying mechanisms. non-alcoholic fatty liver disease; Microbiota; RNA-seq Library Construction and Sequencing Binbin Zhang Junping Shi EMBARGO https://creativecommons.org/licenses/by-nc-nd/4.0/ dataset Science Data Bank