2026-10-12T20:22:50Z https://www.scidb.cn/oai

10.57760/sciencedb.32608 2026-05-28T18:23:53Z

2026-05-28 Modulation of tumor-derived exosomes and reprogramming of cancer-associated fibroblasts for colorectal cancer therapy doi:10.57760/sciencedb.32608 en This study investigates whether and how CRC-derived hypoxic exosomes regulate NAF-to-CAF activation and promote angiogenesis . This hypothesis is supported by multiple machine learning algorithms, clinical data, molecular and genomic analyses, functional status profiling, drug response evaluation, trajectory inference, and cell–cell communication studies using bulk multi-omics and single-cell datasets (pan-cancer with ICB therapy or without therapy information, along with in-house CRC scRNA data (CRC_multi_omics.zip), culminating in in vitro/in vivo experimental validation.  colorectal cancer; hypoxia; exosomes; HIF1Α-AS2; miR-33; cancer-associated fibroblasts; angiogenesis Susu Han Tao Huang Xiaoling Yin Ting Wang Qi Shi Yufei Tang Tingting Zhu Song Gao Hua Sui Fenggang Hou PUBLIC https://creativecommons.org/licenses/by/4.0/ dataset http://www.doi.org/10.1186/s12943-026-02661-2 Science Data Bank