2026-10-15T02:19:26Z https://www.scidb.cn/oai

10.57760/sciencedb.32811 2026-04-08T12:09:30Z

2026-04-08 Figure 2 Schematic mechanisms of Western medicine- and traditional Chinese medicine-induced DILI doi:10.57760/sciencedb.32811 en After metabolism, both western drugs and traditional Chinese medicine can induce ROS accumulation and cellular stress (mitochondrial dysfunction, endoplasmic reticulum stress, and BSEP-related bile transport impairment), leading to cell swelling, membrane rupture, and DAMP release, which subsequently activates innate and adaptive immune responses and culminates in hepatocellular injury. Compared with traditional Chinese medicine, Western drugs more often involve gut-liver axis-related amplification of inflammation via circulating PAMP, while traditional Chinese medicine is chemically complex and more frequently presents as idiosyncratic injury associated with genetic susceptibility.  drug-induced liver injury; western medicine; traditional Chinese medicine; acute liver failure; diagnostic biomarkers; genetic susceptibility; individualized pharmacotherapy DONG Jinrui PUBLIC https://creativecommons.org/licenses/by-nc-nd/4.0/ dataset Science Data Bank