2026-10-14T23:09:37Z https://www.scidb.cn/oai

10.57760/sciencedb.32848 2026-06-01T17:46:14Z

2026-06-01 Rare bronchiolar adenoma with significant basal cell hyperplasia and squamous metaplasia doi:10.57760/sciencedb.32848 en BA/CMPT is a rare benign lung tumor characterized by nodular proliferation of bilayered bronchiolar-type epithelium with a continuous layer of basal cells. Based on the composition of surface cells, it is divided into proximal type BA and distal type BA. There are also some cases of incomplete or absent basal cells. Recently, some cases of driver mutations or malignant transformations have been reported. However, the nature of BA/CMPT remains controversial. Some investigators considered CMPT as a precursor of IMA 1,2. Sun et al.3 reported a case of multiple pulmonary BA with squamous metaplasia and budding growth, which suggested that it had the potential to transform into squamous cell carcinoma. Zhou et al.4 presented histological evidence of squamous cell carcinoma caused by the malignant transformation of BA, expanding its connection with malignant transformation. To date, there were only a few articles that describe BA with extensive BCH and squamous metaplasia5. Based on H&E staining and IHC, we diagnosed our patient as BA with significant BCH and squamous metaplasia, providing more morphological information on the pre-malignant phase of BA. However, future studies are necessary to fully understand the relationship between BA and its malignant transformation. Bronchiolar adenoma/ciliated muconodular papillary tumor; basal cell hyperplasia; diagnosis Chun Qing Ning Zhou Qi Ke RESTRICTED dataset Science Data Bank