2026-10-12T04:31:16Z https://www.scidb.cn/oai

10.57760/sciencedb.33494 2025-12-18T18:11:50Z

2025-12-18 Candindoles A and B, heterozygous terphenyl-indole alkaloids with antifungal and cytotoxic activities from the marine-derived fungus Aspergillus candidus HNNU0546 doi:10.57760/sciencedb.33494 en Three previously undescribed indole alkaloids candindoles A-C (1-3), along with five known analogues (4-8), were isolated from the marine-derived fungus Aspergillus candidus HNNU0546. Structurally, 1 and 2 represent the first terphenyl-indole piperazine alkaloid hybrids, featuring unprecedented backbones. Their structures including absolute configurations, were elucidated by extensive spectroscopic methods, DP4+ probability analysis and ECD calculations. A plausible biosynthetic pathway for 1 is proposed. Compound 1 exhibited moderate growth-inhibitory activity against the plant pathogenic fungus of Alternaria sp. with an EC50 value of 19.21 ± 0.26 µM, while compounds 1 and 2 showed significant cytotoxicity towards human rhabdomyosarcoma cells A673 with IC50 values of 7.72 and 8.89 µM, respectively, comparable to the positive control cisplatin.  Aspergillus candidus; cold-seep-derived fungus; terphenyl-indole piperazine alkaloid; anti-fungal; cytotoxicity Liu Yiyi Chen Haixin Chen Guangying Nong Xuhua Han Zhuang PUBLIC https://creativecommons.org/licenses/by-nc-nd/4.0/ dataset Science Data Bank