2026-10-11T19:13:58Z https://www.scidb.cn/oai

10.57760/sciencedb.33741 2026-06-15T10:57:42Z

2026-06-15 Immunogenicity of Recombinant Rabies Virus-Vectored Multivalent Vaccines Expressing FCV VP1 and FHV-1 gB/gD Genes doi:10.57760/sciencedb.33741 en To develop a safe and effective multivalent vaccine against feline calicivirus (FCV) and feline herpesvirus 1 (FHV-1), two recombinant rabies virus (RABV) vaccines expressing the FCV VP1 and FHV-1 gB/gD genes were constructed. The exogenous genes showed stable inheritance, and the recombinant viruses exhibited growth kinetics similar to the parental strain. After verifying the viral pathogenicity, the recombinant virus vaccines elicited neutralizing antibody responses against FCV, FHV-1, and RABV, and conferred effective protection. rabies virus; vaccine; neutralizing antibody; feline calicivirus; feline herpesvirus 1 Yang Wang Yueze Wang Songze Zhao Hongling He Xiaolong Li Yinyi Liang Jiahao Wang Lerong Xin Nuan Chen Wanxing Xie Shile Huang Jun Luo Xiaofeng Guo PUBLIC https://creativecommons.org/licenses/by/4.0/ dataset Science Data Bank