2026-10-10T21:58:43Z https://www.scidb.cn/oai

10.57760/sciencedb.33960 2026-04-28T10:06:49Z

2026-04-28 Exploring the Protective Mechanism of 8-hydroxygenistein on high-altitude lung injury based on network pharmacology and animal experiments doi:10.57760/sciencedb.33960 en Lung function was measured, and lung tissues were collected. Pathological changes were evaluated by HE staining. Lung water content and vascular permeability were measured to assess pulmonary edema and barrier function. Oxidative stress was evaluated by detecting hydrogen peroxide (H₂O₂), malondialdehyde (MDA), superoxide dismutase (SOD), and glutathione (GSH) levels in lung tissue using assay kits. Inflammatory response was assessed by measuring interleukin-1β (IL-1β), tumor necrosis factor-α (TNF-α), and interleukin-6 (IL-6) levels in lung tissue via enzyme-linked immunosorbent assay (ELISA). Protein expression was analyzed by Western blot. 8-hydroxygenistein; high-altitude lung injury; network pharmacology; oxidative stress; inflammatory response; PI3K/AKT signaling pathway He Xin Wen Yue Ma Chuan Chen Keming jing lin lin PUBLIC https://creativecommons.org/licenses/by/4.0/ dataset Science Data Bank