2026-10-14T18:20:33Z https://www.scidb.cn/oai

10.57760/sciencedb.34224 2025-12-30T16:46:47Z

2025-12-30 The 3C-like serine protease activity of porcine astrovirus nsp1a/3 mediates mitochondrial apoptosis and MAVS cleavage to facilitate viral replication and antagonize type I interferon response doi:10.57760/sciencedb.34224 en This study demonstrated through an in vitro infection model that Porcine Astrovirus type 1(PAstV1) infection of PK-15 cells could induce apoptosis via the mitochondrial pathway. Moreover, the 3C-like serine protease region (nsP1a/3) in the polyprotein nsP1a possesses dual activities of inducing mitochondrial apoptosis through MAVS protein and antagonizing type I interferon. PAstV1; nsP1a/3; MAVS; mitochondrial apoptosis ; type I-IFN; virus infection Yiyang Du Yifeng Qin PUBLIC https://creativecommons.org/licenses/by/4.0/ dataset http://www.doi.org/10.1371/journal.ppat.1013987 Science Data Bank