2026-10-12T17:29:42Z https://www.scidb.cn/oai

10.57760/sciencedb.35849 2026-01-21T15:36:01Z

2026-01-21 RNA sequencing of lymph nodes from wild-type mice and TREM2 knockout mice. doi:10.57760/sciencedb.35849 en In this study, retinal ischemia–reperfusion (IR) models were established in both wild-type (WT) mice and TREM2 knockout (TREM2⁻/⁻) mice. Cervical lymph nodes, which serve as the ocular draining lymph nodes, were then collected from WT control, TREM2⁻/⁻ control, WT IR, and TREM2⁻/⁻ IR mice for bulk RNA sequencing. This analysis aimed to investigate the effects of TREM2 deficiency on retinal and systemic immune responses in the IR model, thereby elucidating the critical role of TREM2 in immune regulation. RNA sequencing; TREM2; lymph nodes Chen Gong Huihui Chen PUBLIC https://creativecommons.org/licenses/by-nc/4.0/ dataset Science Data Bank