2026-10-14T17:35:14Z https://www.scidb.cn/oai

10.57760/sciencedb.36071 2026-04-30T08:38:00Z

2026-04-30 Quantitative secretome atlas of soluble E-cadherin-driven vascular leakage in the lung pre-metastatic niche of salivary adenoid cystic carcinoma doi:10.57760/sciencedb.36071 en This data set reports the comprehensive, label-free quantitative proteomic profile of conditioned media from high-metastatic (SACC-LM) versus low-metastatic (SACC-83) salivary adenoid cystic carcinoma cells. LC-MS/MS analysis identified and quantified 5,342 proteins (FDR ≤ 1 % at PSM, protein level), of which 1,847 were significantly differentially secreted (≥ 2-fold change, p ≤ 0.05). Bioinformatic enrichment highlighted over-representation of cell-adhesion molecules, serine hydrolases and apical-junction components, with soluble E-cadherin (sE-cad/CDH1) displaying the strongest up-regulation (22-fold) in the metastatic secretome. The inventory provides a resource for investigating tumour-derived factors that destabilise endothelial tight-junctions via the Rac2/LIMK/cofilin-1 axis and offers candidate biomarkers for monitoring or targeting the lung pre-metastatic niche in SACC. E-cadherin; metastasis; Salivary adenoid cystic carcinoma Zhou Jinwen You Quan Jiang Jian Guo Tao Kong Jing RESTRICTED dataset Science Data Bank