2026-10-13T08:31:48Z https://www.scidb.cn/oai

10.57760/sciencedb.36231 2026-01-28T10:19:46Z

2026-01-28 Brain Network Characteristics and Behavioral Correlations in Global Developmental Delay Based on Functional Near-Infrared Spectroscopy doi:10.57760/sciencedb.36231 en Global developmental delay (GDD) involves disruptions in early brain development, yet its underlying functional neurobiology is not fully characterized. Using functional near-infrared spectroscopy (fNIRS) during naturalistic stimulation in 49 children with GDD and 45 healthy controls (HC) aged 2–4 years, we investigated functional brain network organization and local neural activity. We found that children with GDD revealed significant reductions in Eglobal Elocal, CC, and functional connectivity strength within bilateral prefrontal networks, including the dorsolateral prefrontal cortex (DLPFC) and medial prefrontal cortex (mPFC). Additionally, local activity patterns were altered, with hypoactivity in prefrontal and hyperactivity in temporal regions. Network metrics correlated positively with developmental measures of motor, adaptive, and social functions. These findings demonstrate disrupted brain network organization and abnormal neural activity underlying cognitive and motor delays in GDD, highlighting the potential of these neurofunctional markers for early diagnosis and personalized intervention strategies. Global Developmental Delay; Functional Near‑Infrared Spectroscopy; Naturalistic Stimulation Paradigm; Brain Networks; Amplitude of Low-Frequency Fluctuation. Kaili Shi RESTRICTED dataset Science Data Bank