2026-10-13T04:47:19Z https://www.scidb.cn/oai

10.57760/sciencedb.38121 2026-09-10T14:05:21Z

2026-09-10 NOTCH2 promotes EMT progression and M2-like TAM polarization in colorectal cancer doi:10.57760/sciencedb.38121 en This study demonstrates that NOTCH2 effectively promotes tumor progression in colorectal cancer (CRC) by driving the epithelial-mesenchymal transition (EMT) program and modulating the immune microenvironment. Through clinical database analysis, histological validation, and in vitro gain- and loss-of-function assays, we identified that NOTCH2 expression is significantly upregulated in CRC tissues and correlates with advanced clinical stages and poor patient prognosis. Furthermore, functional and mechanistic studies revealed that NOTCH2 activation suppresses the epithelial marker E-cadherin while upregulating the mesenchymal marker Vimentin to accelerate EMT, subsequently inducing M2-like tumor-associated macrophage (TAM) polarization. These findings provide a novel molecular basis for NOTCH2 as a critical oncogenic driver and a potential therapeutic target for CRC. Colorectal Cancer; NOTCH2; Epithelial-Mesenchymal Transition; M2-like Macrophage Polarization; IL-4 Bin Xiong PUBLIC https://creativecommons.org/licenses/by-nc/4.0/ dataset Science Data Bank